Exposure Duration-Dependent Ovarian Recovery in Methoxychlor-Treated Mice
نویسندگان
چکیده
منابع مشابه
Dose-Dependent Estrous Cycle, Ovarian Follicles and Biochemical Contents Reversal in Albino Mice after Exposure to Mancozeb.
Mancozeb, a fungicide of a manganese-zinc ethylenebisdithio-carbamate (EBDC), was administered by gavage at doses of 200, 400, 600 and 800 mg/kg/day to female virgin mice for 30 days. The mice were autopsied on 31st day. Mice were also treated with similar doses for a period of 30 days and the treatment was withdrawn for a further period of 30 days for reversible study. The mice were autopsied...
متن کاملFetal and neonatal exposure to the endocrine disruptor methoxychlor causes epigenetic alterations in adult ovarian genes.
Exposure to endocrine-disrupting chemicals during development could alter the epigenetic programming of the genome and result in adult-onset disease. Methoxychlor (MXC) and its metabolites possess estrogenic, antiestrogenic, and antiandrogenic activities. Previous studies showed that fetal/neonatal exposure to MXC caused adult ovarian dysfunction due to altered expression of key ovarian genes i...
متن کاملPerinatal exposure to methoxychlor enhances adult cognitive responses and hippocampal neurogenesis in mice
During perinatal life, sex steroids, such as estradiol, have marked effects on the development and function of the nervous system. Environmental estrogens or xenoestrogens are man-made chemicals, which animal and human population encounter in the environment and which are able to disrupt the functioning of the endocrine system. Scientific interest in the effects of exposure to xenoestrogens has...
متن کاملPerinatal Exposure to Low-Dose Methoxychlor Impairs Testicular Development in C57BL/6 Mice
Methoxychlor (MXC), an organochlorine pesticide, has adverse effects on male reproduction at toxicological doses. Humans and wild animals are exposed to MXC mostly through contaminated dietary intake. Higher concentrations of MXC have been found in human milk, raising the demand for the risk assessment of offspring after maternal exposure to low doses of MXC. In this study, pregnant mice (F0) w...
متن کاملdose-dependent estrous cycle, ovarian follicles and biochemical contents reversal in albino mice after exposure to mancozeb.
mancozeb, a fungicide of a manganese-zinc ethylenebisdithio-carbamate (ebdc), was administered by gavage at doses of 200, 400, 600 and 800 mg/kg/day to female virgin mice for 30 days. the mice were autopsied on 31st day. mice were also treated with similar doses for a period of 30 days and the treatment was withdrawn for a further period of 30 days for reversible study. the mice were autopsied ...
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ژورنال
عنوان ژورنال: Birth Defects Research Part B: Developmental and Reproductive Toxicology
سال: 2015
ISSN: 1542-9733
DOI: 10.1002/bdrb.21164